A new framework reveals Alzheimer’s disease is far more complex than previously believed. Rather than being a disease where the same causes produce the same outcomes, researchers found three different models for the disease, each with its own character…

People with untreated depression have lower levels of mitochondrial proteins. For those who responded to the SSRI antidepressants, the proteins returned to a normal level, but showed no increase in those who did not respond to medication.

Rare variants of the autism-associated ANK2 gene alter the architecture and organization of neurons, potentially contributing to autism and neurodevelopmental comorbidities.

A class of drugs called BACE1 inhibitors, originally designed to treat Alzheimer’s disease, shows potential for the treatment of glioblastoma brain cancer.

Study identifies a significant way in which a disrupted circadian clock drives inflammation in the body’s immune cells.

Stem cells collected from the placentas of women who gave birth to healthy babies could reduce neuroinflammation and reduce brain injury in growth-restricted babies.

People with older-looking brains were born with lower birth weight and genes for smaller brains compared to those with normal aging brains, a new study reports. As both factors present early in life, researchers say “brain age” is likely related to ear…

Researchers have identified a new gene called Tango10 which plays a key role in daily circadian behavioral rhythms.

A new study reveals there is a genetic component to spatial memory in Mountain Chickadees.

Researchers have identified a new, rare neurodevelopmental disorder associated with a homozygous mutation in the PRDM13 gene. Features of the disorder included intellectual disabilities, ataxia with cerebellar hypoplasia, and delayed puberty with hypog…

Dasatinib, an FDA-approved drug for chronic myeloid leukemia, and an experimental drug for liver cancer reduced neuroinflammation, tau phosphorylation, and amyloid secretion in cell cultures of post-mortem brain samples of those with the APOE4 Alzheime…

Post-mortem studies of brain tissue from ALS patients reveal an abnormal form of tau is present in novel brain areas, and the tau interacts with DRP1. The tau appears to cause the brain cell’s mitochondria to fragment and increase oxidative stress. Red…

The combination of bad air quality and a genetic predisposition raises the risk of a person developing depression significantly more than each factor in isolation.

During development, different populations of neurons required for building connections between brain areas share similar genetic programs.

Transgenic three-banded panther worms are helping researchers uncover vital clues about regeneration.

Deleting ABI3, a gene associated with Alzheimer’s disease, significantly increased amyloid-beta accumulation in the brain and decreased the amount of microglia around amyloid-plaques, researchers report.

A study of genetic data from people with autism and congenital heart disease identified 23 genes associated with heart disease. 12 of the genes were previously unknown.

In both aging human and mouse experiments, researchers identified a link between the MEF2 gene and cognitive resilience. Findings suggest enhancing MEF2 activity could protect the brain against age-related dementia.

Brain organoids can be used to study molecular mechanisms that drive brain aging and neurodegenerative disorders. The mini-brains allow for the testing of molecules that could become potential therapeutic treatment options for neurodegenerative diseases.

Inhibiting the NHE6 gene abolished the formation of amyloid-beta plaques in mouse models of Alzheimer’s disease.